GKS. It has a pronounced anti-inflammatory and anti-allergic feat, has anti-shock and immunosuppressive activity. Affects various hope of metabolism: increases the height of glucose in the blood, has a catabolic manipulation, promotes the redistribution of adipose tissue, can induce osteoporosis, causes the retention of sodium and water ions in the body, increases blood pressure. Affects inflammatory spores in connective tissue and reduces the ability to form scar tissue. Pharmacokinetics
Prednisone is an inactive substance that is subsequently absorbed from the gastrointestinal tract into the liver and is converted into an active metabolite, prednisolone. Plasma protein binding of prednisolone is 90%. Prednisolone further undergoes biotransformation in the liver, kidneys and bronchi to oxidized forms, which form conjugates with sulfuric and glucuronic acids. It is excreted by the kidneys mostly unchanged.
When indicated for a history of psoriasis, high-dose prednisone is prescribed under close medical supervision. About diabetes mellitus is prescribed only for about absolute indications, in other words, for the prevention of alleged insulin resistance. The presence of nonspecific infections is used with caution and subject to simultaneous chemotherapy or antibiotic therapy. To be latent forms of tuberculosis, prednisone can be acquired in combination with anti-tuberculosis drugs.Indication of the active substance PREDISON